β2-Adrenergic Signaling Switches from Cardioprotective to Cardiotoxic in Acute vs. Chronic Oxidative Stress
Giovanni Fajardo, Mingming Zhao, Gwanghyun Jung, Viswanathan Rajagopalan, Michael J Coronado, Sushma Reddy, Daniel Bernstein
This study shows that β2-adrenergic receptor signaling is cardioprotective in acute oxidative stress but cardiotoxic in chronic stress, with implications for β-blocker use in cardiovascular disease.
bioRxiv · Apr 29, 2026 · PreprintCell Biology