Cell BiologybioRxivPreprint
Feedback regulation between FOXM1 and APC/CCdh1 determines the changes in cell cycle dynamics during aging
Ana Rita Araújo, Filipa Gaspar-Silva, Elsa Logarinho
The paper investigates how aging affects cell cycle dynamics by examining the feedback regulation between FOXM1 and APC/CCdh1 in human fibroblasts, finding that FOXM1 repression and increased FZR1/Cdh1 levels contribute to cellular senescence.