Elsa Logarinho

FOXM1 enhances DNA repair in aged cells to maintain the peripheral heterochromatin barrier to senescence enhancers

This study shows that restoring FOXM1 activity in aged cells reduces DNA damage and epigenetic changes, inhibiting senescence enhancers and offering a therapeutic approach to aging.

Brain biomechanics governs mitotic fidelity of embryonic neural progenitors

This study shows that biomechanical stress in embryonic neural progenitors affects mitotic fidelity through cortical actin and tension.

Lonafarnib Partially Reverses Cardiac Senescence in Human and Mouse Progeria Models via Autophagy Activation

This study identifies lonafarnib as a potential therapy for progeria-related cardiac senescence by activating autophagy and reducing progerin expression in human and mouse models.

FOXM1 expression reverts aging chromatin profiles through repression of the senescence-associated pioneer factor AP-1

This study shows FOXM1 reverts aging chromatin profiles by repressing AP-1, a senescence-associated pioneer factor, in human fibroblasts.

Chemical enhancement of DNA repair in aging

This study shows a small-molecule agonist of KIF2C enhances DNA repair and mitigates aging phenotypes in progeria and Down syndrome models.

Feedback regulation between FOXM1 and APC/CCdh1 determines the changes in cell cycle dynamics during aging

The paper investigates how aging affects cell cycle dynamics by examining the feedback regulation between FOXM1 and APC/CCdh1 in human fibroblasts, finding that FOXM1 repression and increased FZR1/Cdh1 levels contribute to cellular senescence.