Author

Hiroyuki D. Sakai

Soka UniversityORCID 0000-0003-3583-0285Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:metagenomics· 2 Approach:microscopy & imaging analysis· 2 Assay:bulk RNA-seq· 1 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Debnath GhosaliD· 3 shared Norio KurosawaiD· 3 shared Doulin C. ShepherdiD· 2 shared Manasi MudaliyariD· 2 shared Matthew D. JohnsoniD· 2 shared Michiru ShimizuiD· 2 shared Moriya OhkumaiD· 2 shared Takuro NunouraiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

Debnath GhosalORCID

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintJun 4, 2026

A Tripartite Co-culture System Reveals Defensive Mutualism Between a Nanobdellati Symbiont and Its Host

Hiroyuki D. Sakai, Sabine Schwarzer, Satoshi Nakagawa…·Tessa E. F. Quax

The paper establishes a tripartite co-culture system to study defensive mutualism between a Nanobdellati symbiont and its host, revealing glycan-mediated protection against viral infection.

DOI 10.64898/2026.06.04.730037

proteomicscryo-EM

𝕏 PostBluesky

MicrobiologyNature CommunicationsPeer-reviewedAug 16, 2024

Novel cell-to-cell interactions revealed by cryotomography of a DPANN coculture system

Matthew D. Johnson, Doulin C. Shepherd, Hiroyuki D. Sakai…·Debnath Ghosal

This study uses cryo-ET to reveal intercellular nanotubes between a DPANN archaeon and its host, providing insights into host-DPANN communication and proteomic changes during symbiosis.

11 citations

imagingmicroscopy & imaging analysis

𝕏 PostBluesky

MicrobiologyThe ISME JournalPeer-reviewedJan 1, 2024

A large attachment organelle mediates interaction between a novel Nanobdellota archaeon YN1 and its host

Matthew D. Johnson, Hiroyuki D. Sakai, Bindusmita Paul…·Debnath Ghosal

This study isolates and characterizes a novel Nanobdellota archaeon and its host, revealing an attachment organelle that mediates their ectosymbiotic interaction.

10 citations

metagenomicsexperimental assay

𝕏 PostBluesky