BioinformaticsbioRxivPreprint
SoluProtMut: Siamese Deep Learning for Predicting Solubility Effects of Protein Mutations with Experimental Validation
Jan Velecký, Hana Faldynová, Pedro Hermosilla…·Stanislav Mazurenko
The paper introduces SoluProtMut, a Siamese deep learning model for predicting solubility effects of protein mutations, validated experimentally on 277 mutants.
DOI 10.1101/2025.09.26.676459