Uwe T. Bornscheuer

This study uses ultrahigh-throughput screening to identify mutations in dehalogenases that modulate substrate access and binding, revealing distal functional effects on enzyme dynamics.

The paper identifies PAL3 in Arabidopsis as a novel enzyme converting 3-carboxy-tyrosine into carboxy-p-coumaric acid, reclassifying it as a 3-carboxy-tyrosine ammonia lyase.

This study engineers Pseudomonas putida KT2440 to co-utilize five plastic monomers from mixed plastics, achieving complete substrate depletion and producing (R)-3-hydroxybutyrate.

The paper introduces SoluProtMut, a Siamese deep learning model for predicting solubility effects of protein mutations, validated experimentally on 277 mutants.

The paper uses molecular dynamics simulations to uncover the binding pathway of PET hydrolases into PET material and identifies key residues affecting PET entry.

This study identifies SusC/D-like proteins in marine Gammaproteobacteria for fructan utilization, challenging the notion that these proteins are exclusive to Bacteroidota.