Author

Raja R. Seethala

University of PittsburghORCID 0000-0003-3617-075XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Brian Robert IsettiD· 2 shared Carl Kim· 2 shared Carly ReederiD· 2 shared Dan Paul ZandbergiD· 2 shared Heath Devin SkinneriD· 2 shared Jason J. LukeiD· 2 shared Katelyn Smith· 2 shared Krishna Beer SinghiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Brian Robert IsettORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJun 16, 2026

Integrative multi-omic analysis identifies tumor-intrinsic p38 as a driver of immune exclusion in human epithelial cancers

Rebekah Dadey, Krishna Beer Singh, Rose Doerfler…·Riyue Bao

This study identifies tumor-intrinsic p38 activation as a driver of immune exclusion in epithelial cancers and suggests it as a therapeutic target to overcome immunotherapy resistance.

DOI 10.64898/2026.06.11.731716

humanscRNA-seq

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Cancer BiologybioRxivPreprintJun 24, 2025

Integrating Artificial Intelligence-Driven Digital Pathology and Genomics to Establish Patient-Derived Organoids as a Novel Alternative Model for Drug Response in Head and Neck Cancer

Rose Doerfler, Jie Chen, Carl Kim…·Riyue Bao

This study establishes patient-derived organoids (PDOs) for HNSCC drug response testing, integrating AI-driven histopathology and multi-omics analysis to create a scalable preclinical model.

3 citations

humanbulk RNA-seq

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