Author

Krishna Beer Singh

University of PittsburghORCID 0000-0002-4052-4373Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:deep learning· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Brian Robert IsettiD· 2 shared Carl Kim· 2 shared Carly ReederiD· 2 shared Dan Paul ZandbergiD· 2 shared Heath Devin SkinneriD· 2 shared Jason J. LukeiD· 2 shared Katelyn Smith· 2 shared Lazar N. VujanoviciD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Brian Robert IsettORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Integrative multi-omic analysis identifies tumor-intrinsic p38 as a driver of immune exclusion in human epithelial cancers

Rebekah Dadey, Krishna Beer Singh, Rose Doerfler, Riley Santiago, Brian Robert Isett, Christopher Deitrick, Carl Kim, Sarah Newman, Marion Joy, Katelyn Smith, Carly Reeder, Armando P. Signore, Ernest Michael Meyer, Tullia Carmela Bruno, Aditi Kulkarni, , Riyue Bao

This study identifies tumor-intrinsic p38 activation as a driver of immune exclusion in epithelial cancers and suggests it as a therapeutic target to overcome immunotherapy resistance.

bioRxiv · Jun 16, 2026 · PreprintCancer Biology

Integrating Artificial Intelligence-Driven Digital Pathology and Genomics to Establish Patient-Derived Organoids as a Novel Alternative Model for Drug Response in Head and Neck Cancer

Rose Doerfler, Jie Chen, Carl Kim, Joshua D. Smith, Micah K. Harris, Krishna Beer Singh, Brian Robert Isett, Rebekah Dadey, Daniel D. Brown, Adrian V. Lee, Xuefeng Wang, Matthew E. Spector, Seungwon Kim, Shaum Sridharan, Kevin J. Contrera, , Riyue Bao

This study establishes patient-derived organoids (PDOs) for HNSCC drug response testing, integrating AI-driven histopathology and multi-omics analysis to create a scalable preclinical model.

bioRxiv · Jun 24, 2025 · PreprintCancer Biology