Megan K. Ruhland

Experimental pMHC melting-temperature stability ranked in vivo CD8+ T cell responses of 25 mouse neoantigens better than affinity assays or nine in silico predictors.

This study shows that migratory type 1 dendritic cells are more effective than lymph node resident type 1 dendritic cells in priming CD8+ T cells in tumor and inflamed tissues.

This study shows that self-antigen disrupts cDC1-mediated antitumor responses by altering antigen processing and cross-presentation in dendritic cells.

This study reveals that macrophages sample living cells through trogocytosis-like mechanisms, leading to distinct antigen processing and differential CD4/CD8 T cell priming.