Author

Holly Trochet

Montreal Heart InstituteORCID 0000-0003-3665-3575Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:GWAS summary statistics· 3 Research Focus:GWAS / association mapping· 2 Organism:human· 2 Approach:statistical model· 2 Approach:Bayesian inference· 1 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:fine-mapping· 1

Frequent Co-Authors

Julie HussiniD· 2 shared Amina Barhdadi· 1 shared Chris C. A. SpenceriD· 1 shared Éric RhéaumeiD· 1 shared Gavin BandiD· 1 shared Gil McVeaniD· 1 shared Isabel GamacheiD· 1 shared Jean‐Christophe GrenieriD· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersGenetics

Julie HussinORCID

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3 papers

Recent·Most cited

GeneticseLifePeer-reviewedOct 5, 2021

A sex-specific evolutionary interaction between ADCY9 and CETP

Isabel Gamache, Marc‐André Legault, Jean‐Christophe Grenier…·Julie Hussin

The paper identifies a sex-specific evolutionary interaction between ADCY9 and CETP variants associated with dalcetrapib response and cardiovascular traits.

12 citations

humanGWAS summary statistics

𝕏 PostBluesky

GeneticsbioRxivPreprintAug 9, 2020

Comparison of polygenic risk scores for coronary artery disease highlights obstacles to overcome for clinical use

Holly Trochet, Justin Pelletier, Rafik Tadros, Julie Hussin

This paper compares three polygenic risk scores for coronary artery disease and identifies issues with their clinical use due to population structure confounding and missing data effects.

3 citations

humanGWAS summary statistics

𝕏 PostBluesky

GeneticsGenetic EpidemiologyPeer-reviewedMar 28, 2019

Bayesian meta-analysis across genome-wide association studies of diverse phenotypes

Holly Trochet, Matti Pirinen, Gavin Band…·Chris C. A. Spencer

This paper introduces a Bayesian framework for meta-analyzing GWAS across diverse phenotypes, showing increased power compared to frequentist methods.

33 citations

GWAS summary statisticsBayesian inference

𝕏 PostBluesky