Larry Norton

This study identifies high WEE1 expression as a prognostic marker in multiple myeloma, showing it is independently linked to poor survival and associated with dysregulated P53 pathways.

The paper identifies how germline and somatic mutations interact to cause resistance to CDK4/6 inhibitors in breast cancer and proposes a sequential treatment strategy using PARP inhibitors.

The paper shows oncologic therapy increases clonal hematopoiesis with DDR mutations, which predicts risk of therapy-related myeloid neoplasms.