NeuroscienceThe EMBO JournalPeer-reviewed
An Arrayed Genome-Wide Perturbation Screen Identifies the Ribonucleoprotein hnRNP K As Rate-Limiting for Prion Propagation
Merve Avar, Daniel Heinzer, Alana M. Thackray…·Adriano Aguzzi
The paper identifies Hnrnpk as a key regulator of prion propagation through a genome-wide RNAi screen using the QUIPPER assay, showing PSA's ability to reduce prion levels and toxicity in multiple models.
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