Author

Brenen W. Papenberg

National Cancer InstituteORCID 0000-0003-3734-3018Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:fine-mapping· 1 Research Focus:gene regulatory network inference· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Ludmila Prokunina‐OlssoniD· 3 shared Michelle HoiD· 3 shared Oscar Flórez-VargasiD· 3 shared Stephen Jacob ChanockiD· 3 shared Chia-Han Lee· 2 shared Kristine M. JonesiD· 2 shared Wen LuoiD· 2 shared Abdul Rouf BandayiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Ludmila Prokunina‐OlssonORCID

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3 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintMar 7, 2026

Integrative screening identifies functional variants and VNTRs underlying GWAS signals at the 5p15.33 multi-cancer susceptibility locus

Aidan O’Brien, Hyunkyung Kong, Harsh Patel…·Laufey Thora Amundadottir

The paper identifies functional variants and VNTRs at the 5p15.33 locus using fine-mapping, MPRA, and CRISPRi screens, revealing their role in cancer susceptibility through antagonistic pleiotropy.

DOI 10.64898/2026.03.03.26347427

humanwhole-genome sequencing

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Genetic & Genomic MedicinemedRxivPreprintNov 4, 2024

Genetic regulation of TERT splicing contributes to reduced or elevated cancer risk by altering cellular longevity and replicative potential

Oscar Flórez-Vargas, Michelle Ho, Maxwell H. Hogshead…·Ludmila Prokunina‐Olsson

This study identifies VNTR6-1 and rs10069690 as regulators of TERT splicing and expression, influencing cancer risk and telomere dynamics through altered telomerase isoform ratios.

DOI 10.1101/2024.11.04.24316722

humanwhole-genome sequencing

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Genetic & Genomic MedicineNature GeneticsPeer-reviewedJul 14, 2022

Genetic regulation of OAS1 nonsense-mediated decay underlies association with risk of severe COVID-19

Abdul Rouf Banday, Megan Lynn Stanifer, Oscar Flórez-Vargas…·Ludmila Prokunina‐Olsson

The paper identifies a Neandertal introgressed haplotype in the OAS1 gene associated with increased risk of severe COVID-19 and shows it impairs SARS-CoV-2 clearance through genetic regulation of OAS1 expression.

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humanwhole-genome sequencing

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