Author

Chia-Han Lee

National Cancer Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Genetic & Genomic Medicine· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Brenen W. PapenbergiD· 2 shared Ludmila Prokunina‐OlssoniD· 2 shared Michelle HoiD· 2 shared Oscar Flórez-VargasiD· 2 shared Stephen Jacob ChanockiD· 2 shared Abdul Rouf BandayiD· 1 shared Adam J. GehringiD· 1 shared Alicia K. SmithiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Brenen W. PapenbergORCID

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2 papers

Recent·Most cited

Genetic regulation of TERT splicing contributes to reduced or elevated cancer risk by altering cellular longevity and replicative potential

Oscar Flórez-Vargas, Michelle Ho, Maxwell H. Hogshead, Chia-Han Lee, Brenen W. Papenberg, Kaitlin Forsythe, Kristine M. Jones, Wen Luo, Kedest Teshome, Cornelis Blauwendraat, Kimberley J. Billingsley, Mikhail Kolmogorov, Melissa Meredith, Benedict Paten, Raj Chari, , Ludmila Prokunina‐Olsson

This study identifies VNTR6-1 and rs10069690 as regulators of TERT splicing and expression, influencing cancer risk and telomere dynamics through altered telomerase isoform ratios.

medRxiv · Nov 4, 2024 · PreprintGenetic & Genomic Medicine

Genetic regulation of OAS1 nonsense-mediated decay underlies association with risk of severe COVID-19

Abdul Rouf Banday, Megan Lynn Stanifer, Oscar Flórez-Vargas, Olusegun O. Onabajo, Brenen W. Papenberg, Muhammad Atif Zahoor, Lisa J. Mirabello, Timothy J. Ring, Chia-Han Lee, Paul S. Albert, Evangelos Andreakos, Evgeny Arons, Gregory S. Barsh, Leslie G. Biesecker, David L. Boyle, , Ludmila Prokunina‐Olsson

The paper identifies a Neandertal introgressed haplotype in the OAS1 gene associated with increased risk of severe COVID-19 and shows it impairs SARS-CoV-2 clearance through genetic regulation of OAS1 expression.

Nature Genetics · Jul 14, 2022Peer-reviewedGenetic & Genomic Medicine