Lingyan Chen

This study uses Mendelian randomization to identify plasma proteins associated with stroke risk and potential therapeutic targets.

The paper identifies a genetic variant in PROCR that influences protein C and factor VII levels, linking it to both reduced coronary artery disease risk and increased venous thromboembolism risk through opposing inflammatory and thrombotic mechanisms.

This study evaluates genetic risk scores for predicting SLE susceptibility and severity using GWAS data from European and Chinese populations, finding moderate predictive performance and associations with renal disease and age of onset.