David Stacey

This study uses Mendelian randomisation and colocalisation to show CD40 protein levels are not causally linked to depression, but SLC12A5 at the CD40 locus may contribute to depression risk through brain-expressed potassium chloride co-transporter effects.

This study identifies genetic factors underlying personality meta-traits stability and plasticity and their links to psychopathology using GWAS and structural equation modeling.

The paper identifies genetic markers linked to clozapine-induced metabolic dysfunction using Mendelian randomization and colocalization analyses, suggesting potential biomarkers for precision medicine.

This study identifies genetic determinants of blood gene expression and splicing, linking them to molecular phenotypes and health outcomes through QTL analysis and colocalization.

The paper identifies pQTLs for 91 plasma proteins, finds novel associations, and uses MR to uncover causal roles in immune-mediated diseases, suggesting new therapeutic targets.

The paper identifies genetic associations between blood lipid metabolites and cardiometabolic disease loci in South Asian populations using lipidomics data from two studies.

The paper identifies a genetic variant in PROCR that influences protein C and factor VII levels, linking it to both reduced coronary artery disease risk and increased venous thromboembolism risk through opposing inflammatory and thrombotic mechanisms.

The paper identifies 1,927 genetic associations with 1,478 plasma proteins using 10.6 million DNA variants and 3,301 individuals, revealing new drug targets and safety concerns.