Michael J. O’Connell

This paper introduces an autoencoder with orthogonal constraints for multi-omics data integration, showing improved reconstruction and classification performance on cancer data.

This study uses directed evolution in cyanobacteria to identify genetic traits that enhance photosynthesis under salt stress, finding specific mutations in the PSII D1 gene improve stress tolerance.

This study enhances the JIVE method for single-cell RNA sequencing data to correct batch effects and improves its computational efficiency for large-scale datasets.

KOMPUTE imputes missing phenotype summary statistics in the IMPC dataset using conditional distribution properties, outperforming SVD matrix completion methods.