Lorenzo Puche-Aroca

This paper identifies cell-adhesion molecules that prime sensory cortical identity through thalamocortical targeting before thalamic innervation.

The paper generates a single-cell multiomic atlas of the embryonic mouse thalamus, identifies two major glutamatergic lineages, and reveals early lineage divergence that segregates sensory and non-sensory circuits.

The paper shows that prenatal whisker ablation enhances upper lip whisker barrel definition through thalamic transcriptional changes, independent of receptor type and density.

The paper shows neurons and astrocytes in specific brain regions share transcriptional and epigenetic signatures, which are maintained even after reprogramming.