Guillermina López‐Bendito

Purkinje cell intrinsic activity shapes cerebellar development and function

This study shows that Purkinje cell intrinsic activity before synaptic maturation is critical for dendrite growth, connectivity, and cerebellar function, with early disruptions causing severe morphological and functional defects.

A Thalamocortical Cell-Adhesion Code Primes Sensory Cortical Specification

This paper identifies cell-adhesion molecules that prime sensory cortical identity through thalamocortical targeting before thalamic innervation.

Early lineage divergence segregates sensory and non-sensory thalamic circuits

The paper generates a single-cell multiomic atlas of the embryonic mouse thalamus, identifies two major glutamatergic lineages, and reveals early lineage divergence that segregates sensory and non-sensory circuits.

A prenatal window for enhancing spatial resolution of cortical barrel maps

The paper shows that prenatal whisker ablation enhances upper lip whisker barrel definition through thalamic transcriptional changes, independent of receptor type and density.

Spontaneous thalamic activity modulates the cortical innervation of the primary visual nucleus of the thalamus

This study shows that spontaneous thalamic activity influences the timing and spatial organization of corticogeniculate innervation in the developing visual thalamus.

Astrocytes and neurons share brain region-specific transcriptional signatures

The paper shows neurons and astrocytes in specific brain regions share transcriptional and epigenetic signatures, which are maintained even after reprogramming.