Author

César Cunha

Broad InstituteORCID 0000-0003-3811-2932Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 3 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Research Focus:GWAS / association mapping· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

María J Romero-LadoiD· 3 shared Raquel MartíneziD· 3 shared Tuomas O. KilpeläineniD· 3 shared Mario García‐UreñaiD· 2 shared Melina ClaussnitzeriD· 2 shared Ruth J. F. LoosiD· 2 shared Alfredo Ramı́reziD· 1 shared Céline BellengueziD· 1 shared

Activity by Year

2023-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

María J Romero-LadoORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintAug 22, 2026

Genetic architecture of Alzheimer's disease is enriched in peripheral immune and metabolic programs

César Cunha, Marc Pielies Avelli, María J Romero-Lado…·Tuomas O. Kilpeläinen

This study identifies peripheral immune and metabolic tissues as key contributors to Alzheimer's disease genetic risk, independent of brain-specific factors.

2 citations

humanbulk RNA-seq

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Genetic & Genomic MedicinemedRxivPreprintAug 17, 2026

Genomics link obesity and type 2 diabetes to Alzheimers disease to unveil novel biological insights

César Cunha, Mario García‐Ureña, Raquel Martínez…·Ruth J. F. Loos

This study links obesity and type 2 diabetes to Alzheimer's disease through genetic and transcriptomic analyses, identifying shared pathways and potential drug targets.

DOI 10.64898/2026.02.10.26344393

humanbulk RNA-seq

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Genetic & Genomic MedicinemedRxivPreprintApr 1, 2026

Genome-Wide Discovery Reveals Adipose-Specific and Systemic Regulators of Insulin Resistance

Mario García‐Ureña, Pearlyn Jia Ying Toh, Raquel Martínez…·Tuomas O. Kilpeläinen

This study identifies 282 genetic loci associated with insulin resistance through multi-trait GWAS, highlighting adipose-specific and systemic regulators and potential therapeutic targets.

DOI 10.64898/2026.03.31.26349822

humanGWAS summary statistics

𝕏 PostBluesky

NeuroscienceTrafficPeer-reviewedMay 23, 2023

Deacidification of distal lysosomes by neuronal aging drives synapse loss

Tatiana Burrinha, César Cunha, Michael J. Hall…·Cláudia Guimas Almeida

The paper identifies deacidification of distal lysosomes in aged neurons as a mechanism driving synapse loss and shows that restoring acidification can reverse synaptic decline.

35 citationstop 3%

mouseexperimental assay

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