Haoran Chen

CytoSpatio models spatial relationships between cell types across tissues using multirange, multitype point processes and generates synthetic tissue structures.

3DCellComposer uses 2D segmentation models to generate accurate 3D cell segmentations without requiring additional training or human annotations.

This paper describes the construction and usage of the Human Reference Atlas (HRA) v2.0, which integrates multiscale data across 36 organs and provides tools for analysis and visualization.

The paper evaluates cell segmentation methods using automated metrics instead of human reference segmentations, finding two deep learning methods perform best with improved results via postprocessing.