Author
Matthew Ruffalo
Carnegie Mellon UniversityORCID 0000-0003-2222-6169Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2018-2026 · peak 4/yrCo-Author Collaboration Network
10 top collaborators · 36 mutual co-author links8 papers
Recent·Most cited
- BioinformaticsCell SystemsPeer-reviewed
Flexible and robust cell type annotation for highly multiplexed tissue images
Huangqingbo Sun, Shiqiu Yu, Anna Martinez Casals…·Robert F. Murphy
This paper introduces RIBCA, a tool for automated cell type annotation in multiplexed tissue images, capable of annotating over 3 million cells across 40 human tissues without manual intervention.
- BioinformaticsMethodsPeer-reviewed
3DCellComposer - A Versatile Pipeline Utilizing 2D Cell Segmentation Methods for 3D Cell Segmentation
Haoran Chen, Ted Zhang, Matthew Ruffalo, Robert F. Murphy
3DCellComposer uses 2D segmentation models to generate accurate 3D cell segmentations without requiring additional training or human annotations.
6 citations - BioinformaticsGenome ResearchPeer-reviewed
A unified analysis of atlas single cell data
Hao Chen, Nam D. Nguyen, Matthew Ruffalo, Ziv Bar‐Joseph
This paper introduces GIANT, a method for integrating atlas-scale single cell data from multiple modalities and tissues, creating a unified gene embedding space that reflects gene functions and regulations.
- BioinformaticsNature MethodsPeer-reviewed
Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas Construction and Usage
Katy Börner, Philip D. Blood, Jonathan C. Silverstein…·Vilas Menon
This paper describes the construction and usage of the Human Reference Atlas (HRA) v2.0, which integrates multiscale data across 36 organs and provides tools for analysis and visualization.
51 citationstop 1% - BioinformaticsbioRxivPreprint
HBM-CITEseq: a uniform CITE-seq processing pipeline for the HuBMAP Consortium
The paper introduces HBM-CITEseq, a CITE-seq processing pipeline for the HuBMAP Consortium that aligns with existing RNA-seq pipelines and is available on GitHub.
DOI 10.1101/2022.12.19.521058 - BioinformaticsPLoS Computational BiologyPeer-reviewed
CINS: Cell Interaction Network inference from Single cell expression data
Ye Yuan, Carlos Cosme, Taylor Sterling Adams…·Ziv Bar‐Joseph
CINS infers differential cell-cell interactions between conditions using scRNA-Seq data and identifies the proteins involved in these interactions.
- BioinformaticsNature CommunicationsPeer-reviewed
scQuery: a web server for comparative analysis of single-cell RNA-seq data
Amir Alavi, Matthew Ruffalo, Aiyappa Parvangada…·Ziv Bar‐Joseph
scQuery provides a web server for supervised comparison of single-cell RNA-seq datasets, showing supervised methods outperform unsupervised approaches in cell type identification.