Aneta Mikulášová

This study uses SCID-rab PDX models to analyze genomic and transcriptomic features of multiple myeloma, revealing selection of pre-existing high-risk clones.

EpiATLAS provides a comprehensive collection of human reference epigenomes to advance epigenomic research and understanding of cellular function and disease.

The paper identifies an evolutionarily conserved enhancer within the MYEOV locus that regulates CCND1 in humans and mice, suggesting a non-coding role in cancer.

The paper identifies H3K4me3 broad domains formed by super-enhancer translocations in B-cell and T-cell malignancies, linking them to oncogene activation.

The paper identifies de novo mutations as a significant genetic cause of male infertility, finding several candidate genes and an enrichment of loss-of-function and missense mutations in intolerant genes.

The paper uses polymer simulations to study chromatin structure changes at genomic rearrangements in B-cells and shows how these changes affect proto-oncogene expression.