Cheng Zhang

The paper identifies multiple synergy modes of transcription factors in the IFNβ enhancer that enable stimulus-specific regulation of IFNβ expression.

This study uses existing transcriptomic data and crowdsourcing to derive temporal host response signatures for SARS-CoV-1 and SARS-CoV-2, identifying key genes and potential treatments.

This study identifies BRF1 as a nucleolar protein that promotes Pol I-directed transcription and tumor cell growth by modulating the recruitment of Pol I transcription machinery factors.

The paper uses single-cell chromatin accessibility to identify cell type- and state-specific regulatory programs associated with type 2 diabetes risk.