Cheng Zhang

Dissecting the TMEM132A-EGFR Dependency to Unlock Translational Therapeutic Opportunities for Pan-Solid Tumor

This paper identifies TMEM132A as a pan-cancer target that stabilizes EGFR and drives lipid synthesis, and develops a nanobody to inhibit this interaction, showing antitumor activity in resistant models.

Towards building a World Model to simulate perturbation-induced cellular dynamics by AlphaCell

AlphaCell simulates perturbation-induced cellular dynamics by addressing limitations in current models through three innovations: latent manifold rectification, biological reality reconstruction, and universal state transition.

Harnessing the Embryo Antitumor Factor NEPN for Broad-Spectrum Cancer Immunotherapy via Dual Modulation of Tumor Progression and Immune Suppression

This study identifies NEPN as a tumor-suppressive embryonic factor that enhances cancer immunotherapy by modulating TGFβ1 signaling and immune responses in both non-solid and solid tumors.

Aging-dependent dysregulation of EXOSC2 is maintained in cancer as a dependency

The paper investigates how aging-dependent dysregulation of EXOSC2 affects cellular traits and finds that PPP2R5E, a PP2A phosphatase subunit, is a key target of EXOSC2, with this regulation maintained in stem cells and cancer.

TIA1 Mediates Divergent Inflammatory Responses to Tauopathy in Microglia and Macrophages

This study shows TIA1 regulates divergent inflammatory responses in microglia and macrophages, reducing brain inflammation and tau pathology while increasing peripheral inflammation.