Author

Hong Chen

Sentieon (United States)ORCID 0000-0003-3876-6514Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Hong Chen1 paper · The University of Texas MD Anderson Cancer Center

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Organism:human· 2 Assay:long-read sequencing· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Research Focus:variant effect prediction· 2 Assay:whole-genome sequencing· 2 Approach:experimental assay· 1

Frequent Co-Authors

Donald N. FreediD· 2 shared Hanying Feng· 2 shared Haodong CheniD· 2 shared Jinnan HuiD· 2 shared Zhipan LiiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersBioinformatics

Donald N. FreedORCID

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2 papers

Recent·Most cited

BioinformaticsFrontiers in BioinformaticsPeer-reviewedJan 5, 2026

Accelerated, Accurate, Hybrid Short and Long Reads Alignment and Variant Calling

Jinnan Hu, Donald N. Freed, Hanying Feng…·Haodong Chen

The paper introduces DNAscope Hybrid, a pipeline combining short and long-read sequencing for improved variant calling accuracy and efficiency.

4 citationstop 5%

humanwhole-genome sequencing

𝕏 PostBluesky

BioinformaticsbioRxivPreprintNov 14, 2025

Accelerated and High-Accuracy Variant Calling on Oxford Nanopore Technologies Sequencing Data with the Sentieon DNAscope LongRead and Hybrid Pipelines

Jinnan Hu, Donald N. Freed, Hanying Feng…·Haodong Chen

The paper introduces and benchmarks DNAscope LongRead and Hybrid pipelines for variant calling on ONT data, showing high accuracy and efficiency in SNP, Indel, and Structural Variant detection.

DOI 10.1101/2025.11.14.688541

humanwhole-genome sequencing

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