Author

Hanying Feng

Sentieon (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 4

Signature Assays, Organisms & Methods

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Research Focus:variant calling· 4 Assay:whole-genome sequencing· 4 Assay:long-read sequencing· 3 Research Focus:benchmarking· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:variant effect prediction· 2

Frequent Co-Authors

Donald N. FreediD· 3 shared Haodong CheniD· 3 shared Jinnan HuiD· 3 shared Zhipan LiiD· 3 shared Hong CheniD· 2 shared Adrián Muñoz‐BarreraiD· 1 shared Alexey Dolgoborodov· 1 shared Alexey KolesnikoviD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBioinformatics

Donald N. FreedORCID

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4 papers

Recent·Most cited

Accelerated, Accurate, Hybrid Short and Long Reads Alignment and Variant Calling

Jinnan Hu, Donald N. Freed, Hanying Feng, Hong Chen, Zhipan Li, Haodong Chen

The paper introduces DNAscope Hybrid, a pipeline combining short and long-read sequencing for improved variant calling accuracy and efficiency.

Frontiers in Bioinformatics · Jan 5, 2026Peer-reviewedBioinformatics

Accelerated and High-Accuracy Variant Calling on Oxford Nanopore Technologies Sequencing Data with the Sentieon DNAscope LongRead and Hybrid Pipelines

Jinnan Hu, Donald N. Freed, Hanying Feng, Hong Chen, Zhipan Li, Haodong Chen

The paper introduces and benchmarks DNAscope LongRead and Hybrid pipelines for variant calling on ONT data, showing high accuracy and efficiency in SNP, Indel, and Structural Variant detection.

bioRxiv · Nov 14, 2025 · PreprintBioinformatics

Processing UMI Datasets at High Accuracy and Efficiency with the Sentieon ctDNA Analysis Pipeline

Jinnan Hu, Cai Jiang, Yu S. Huang, Haodong Chen, Hanying Feng, Donald N. Freed, Yan Dong Qu, Rui Fan, Zhencheng Su, Weizhi Chen

The paper introduces the Sentieon ctDNA pipeline for accurate and efficient small somatic variant calling from ctDNA sequencing data, showing improved accuracy over existing methods.

bioRxiv · Jun 3, 2022 · PreprintBioinformatics

precisionFDA Truth Challenge V2: Calling variants from short- and long-reads in difficult-to-map regions

Nathan D. Olson, Justin Wagner, Jennifer McDaniel, Sarah H. Stephens, Samuel T. Westreich, Anish G. Prasanna, Elaine Johanson, Emily S. Boja, Ezekiel J. Maier, Omar Serang, David Jáspez, Jose Miguel Lorenzo-Salazar, Adrián Muñoz‐Barrera, Luis A. Rubio‐Rodríguez, Carlos Flores, , Justin M. Zook

The paper evaluates variant calling in difficult genomic regions using short- and long-read sequencing, showing improved performance with new methods and multi-technology approaches.

Cell Genomics · Apr 27, 2022Peer-reviewedBioinformatics