Moshe Szyf A

This study shows that Mbd2 deficiency in mice leads to cognitive and social deficits, altered gene expression, and DNA methylation patterns similar to those in ASD, suggesting Mbd2 is an epigenetic regulator of ASD-risk genes.

This paper introduces a method to study DNA methylation's causal role in gene expression by using CRISPR/dCas9 to block DNA methyltransferase, showing that DNA methylation primarily silences basal promoter activity.

A pilot trial shows diet and lifestyle changes can reverse biological age as measured by DNA methylation clocks.

This study examines epigenetic changes in the mouse prefrontal cortex over time following nerve injury, identifying persistent DNA methylation alterations associated with acute to chronic pain transition.