Author

Daniel M. Sapozhnikov

McGill UniversityORCID 0000-0001-5721-2782Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Organism:mouse· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Moshe Szyf AiD· 2 shared Elad LaxiD· 1 shared Jonathan P. BrittiD· 1 shared Lindsay A. WelikovitchiD· 1 shared Liqing WangiD· 1 shared Niaz MahmoodiD· 1 shared Shafaat Ahmed RabbaniiD· 1 shared Sonia Do CarmoiD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Moshe Szyf AORCID

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2 papers

Recent·Most cited

NeuroscienceTranslational PsychiatryPeer-reviewedJul 13, 2023

Methyl-CpG binding domain 2 (Mbd2) is an Epigenetic Regulator of Autism-Risk Genes and Cognition

Elad Lax, Sonia Do Carmo, Yehoshua Enuka…·Moshe Szyf A

This study shows that Mbd2 deficiency in mice leads to cognitive and social deficits, altered gene expression, and DNA methylation patterns similar to those in ASD, suggesting Mbd2 is an epigenetic regulator of ASD-risk genes.

25 citations

mouseDNA methylation

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Molecular BiologyNature CommunicationsPeer-reviewedSep 29, 2021

Unraveling the functional role of DNA methylation using targeted DNA demethylation by steric blockage of DNA methyltransferase with CRISPR/dCas9

Daniel M. Sapozhnikov, Moshe Szyf A

This paper introduces a method to study DNA methylation's causal role in gene expression by using CRISPR/dCas9 to block DNA methyltransferase, showing that DNA methylation primarily silences basal promoter activity.

87 citationstop 3%

DNA methylationexperimental assay

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