Molecular BiologyProceedings of the National Academy of SciencesPeer-reviewed
Changing protein-DNA interactions promote ORC binding site exchange during replication origin licensing.
Annie Zhang, Larry J. Friedman, Jeff Gelles, Stephen P. Bell
This study investigates how changing protein-DNA interactions enable ORC to switch DNA binding sites during replication origin licensing, revealing a stepwise mechanism involving DNA unbending, sliding, and reduced ORC stability.
15 citations