Author

Chaolong Wang

Huazhong University of Science and TechnologyORCID 0000-0003-3945-1012Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Genetics· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:GWAS / association mapping· 1 Approach:mixed model· 1 Organism:mouse· 1

Frequent Co-Authors

Adolfo CorreaiD· 1 shared Alanna C. MorrisoniD· 1 shared Alex P. ReineriD· 1 shared Andrew D. JohnsoniD· 1 shared Braxton D. MitchelliD· 1 shared Brian E. CadeiD· 1 shared Cathy C. LaurieiD· 1 shared Charles L KooperbergiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperGenetics

Adolfo CorreaORCID

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4 papers

Recent·Most cited

ATF4 alleviates doxorubicin-induced cardiomyopathy through H2S-mediated antioxidation

Shuting Xu, Yan Shi, Xiaoshuai Zhao, Xuhui Chen, Ying Liu, Fan Zhang, Fangchi Yu, Linhao Ruan, Chaolong Wang, Xuejun Jiang, Xiaoding Wang, Guangyu Zhang

This study shows ATF4 protects against doxorubicin-induced cardiomyopathy by enhancing H2S-mediated antioxidation through upregulation of CSE.

bioRxiv · Sep 3, 2025 · PreprintPathology

Accurate estimation of SNP genotypes and genetic relatedness from DNA methylation data

Yi Wei Jiang, Minghan Qu, Minghui Jiang, Xuan Jiang, Shane Fernandez, Tenielle Porter, Simon Matthew Laws, Colin Louis Masters, Huan Guo, Shanshan Cheng, Chaolong Wang

This paper introduces MethylGenotyper, a method to genotype SNPs and estimate genetic relatedness from DNA methylation data, achieving high concordance rates and identifying related individuals in diverse populations.

bioRxiv · Apr 15, 2024 · PreprintBioinformatics

Probabilistic cell/domain-type assignment of spatial transcriptomics data with SpatialAnno

Xingjie Shi, Yi Yang, Xiaohui Ma, Yong Zhou, Zhenxing Guo, Chaolong Wang, Jin Liu

SpatialAnno improves spatial transcriptomics annotation by integrating non-marker genes and spatial information without a reference dataset.

Nucleic Acids Research · Nov 6, 2023Peer-reviewedBioinformatics

Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

Han Chen, Jennifer E. Huffman, Jennifer A. Brody, Chaolong Wang, Seunggeun Lee, Zilin Li, Stephanie M. Gogarten, Tamar Sofer, Lawrence F. Bielak, Joshua C. Bis, John Blangero, Russell Paul Bowler, Brian E. Cade, Michael H. Cho, Adolfo Correa, , Xihong Lin

The paper introduces SMMAT, a variant-set mixed model association test for continuous and binary traits in large-scale WGS studies, showing it controls type I error rates and applies to population structured and related samples.

The American Journal of Human Genetics · Jan 10, 2019Peer-reviewedGenetics