Colin Louis Masters

This paper identifies a stage-specific proteomic signature of Alzheimer's disease using plasma proteomics and finds a proteomic switch associated with disease progression.

This study isolates and characterizes small extracellular vesicles from human plasma using multi-omics approaches, revealing novel protein and lipid profiles with potential biomarker value.

The paper quantifies post-translational modifications of Aβ in brain tissue to distinguish amyloidosis stages in Alzheimer's Disease and related conditions.

The paper uses single molecule techniques to show that different alpha-synuclein polymorphs have distinct growth mechanisms in seed amplification assays, with one polymorph showing increased secondary nucleation.

This paper introduces MethylGenotyper, a method to genotype SNPs and estimate genetic relatedness from DNA methylation data, achieving high concordance rates and identifying related individuals in diverse populations.

This study identifies genetic resilience factors for Alzheimer's disease by constructing polygenic resilience scores that reduce genetic risk penetrance and correlate with polygenic risk scores in unaffected individuals.

The paper identifies 617 novel genomic loci and pathways associated with structural covariance patterns in the human brain using a stochastic multivariate factorization method.

This study identifies 667 genetic loci associated with lipid species and links 186 of them to coronary artery disease through integrative lipidomics and genomics.

The paper describes MRI and PET protocols used in the DIAN study to investigate preclinical Alzheimer's disease and reports key imaging findings.

This study identifies plasma proteome differences associated with APOE e3 and e4 genotypes in Alzheimer's disease, revealing unique and shared molecular pathways involved in disease pathogenesis.

The paper examines cognitive and brain morphology changes from mid-life to older adulthood, finding age-related shifts in cognitive domains and sulcal width patterns.

This study characterizes the lipid composition of brain-derived extracellular vesicles (BDEVs) in Alzheimer's disease and identifies disease-related lipid profile changes.

The paper identifies asymmetric thinning of the cerebral cortex across aging and Alzheimer's Disease, showing that the initially thicker hemisphere thins faster, with this pattern replicated across multiple cohorts.

The paper harmonizes 10,232 structural brain MRIs from 18 studies to create a normative reference of brain development and aging across 3 to 96 years.