The paper identifies genetic factors associated with Alzheimer's disease progression using GWAS and longitudinal data, finding distinct genetic drivers from disease risk.

Alzheimer s Research & Therapy · Apr 25, 2026Peer-reviewedGenetic & Genomic Medicine

Accurate estimation of SNP genotypes and genetic relatedness from DNA methylation data

Yi Wei Jiang, Minghan Qu, Minghui Jiang, Xuan Jiang, Shane Fernandez, Tenielle Porter, Simon Matthew Laws, Colin Louis Masters, Huan Guo, Shanshan Cheng, Chaolong Wang

This paper introduces MethylGenotyper, a method to genotype SNPs and estimate genetic relatedness from DNA methylation data, achieving high concordance rates and identifying related individuals in diverse populations.

bioRxiv · Apr 15, 2024 · PreprintBioinformatics

Polygenic resilience scores capture protective genetic effects for Alzheimers disease

Jiahui Hou, Jonathan Hess, Nicola J. Armstrong, Joshua C. Bis, Benjamin Grenier‐Boley, Ida Karlsson, Ganna Leonenko, Katya T. Numbers, Eleanor K. O’Brien, Alexey A. Shadrin, Anbupalam Thalamuthu, Qiong Yang, Ole A. Andreassen, Henry Brodaty, Margaret Gatz, , Stephen J. Glatt

This study identifies genetic resilience factors for Alzheimer's disease by constructing polygenic resilience scores that reduce genetic risk penetrance and correlate with polygenic risk scores in unaffected individuals.

Translational Psychiatry · Jul 25, 2022Peer-reviewedGenetic & Genomic Medicine

Comprehensive genetic analysis of the human lipidome identifies novel loci controlling lipid homeostasis with links to coronary artery disease

Gemma Cadby, Corey Giles, Phillip E. Melton, Kevin Huynh, Natalie A. Mellett, Thy Duong, Thu Anh Nguyen, Michelle A. Cinel, Alexander Smith, Gavriel Olshansky, Tingting Wang, Marta Brożyńska, Mike Inouye, Nina S. McCarthy, Amir Ariff, , Eric Keith Moses

This study identifies 667 genetic loci associated with lipid species and links 186 of them to coronary artery disease through integrative lipidomics and genomics.

Nature Communications · Jun 6, 2022Peer-reviewedGenetic & Genomic Medicine

Investigating neurotrophin genetics and hippocampal volume

Jaisalmer de Frutos‐Lucas, Michael A. Vacher, Tenielle Porter, Belinda M. Brown, Simon Matthew Laws

This study identifies SNPs in neurotrophic genes associated with hippocampal volume in older adults using UK Biobank data.

bioRxiv · Jan 1, 2022 · PreprintGenetics

BDNF Val66Met moderates the relationship between cardiorespiratory fitness and memory in cognitively normal older adults

Belinda M. Brown, Natalie Castalanelli, Stephanie Ruth Rainey‐Smith, James D. Doecke, Michael Weinborn, Hamid Reza Sohrabi, Simon Matthew Laws, Ralph Nigel Martins, Jeremiah J. Peiffer

This study finds that the BDNF Val66Met polymorphism moderates the effect of cardiorespiratory fitness on visuospatial memory in older adults.

Behavioural Brain Research · Jan 9, 2019Peer-reviewedNeuroscience