BiochemistrybioRxivPreprint
Global Data Fitting Enables Kinetic Dissection of Cullin-RING Ligase-Catalyzed Ubiquitylation: From Substrate Priming to Poly-ubiquitin Chain Formation
Nicholas Purser, Jerry Li, Daniel Scott…·Gary Kleiger
This study uses pre-steady state kinetics and global data fitting to analyze CRL-dependent ubiquitylation, revealing kinetic parameters and catalytic efficiencies across different CRL systems and substrate contexts.
DOI 10.64898/2026.11.04.764329