Yu-Han H. Hsu

The paper identifies three neuron-specific schizophrenia protein networks enriched for genetic and transcriptional perturbations and validates their disruption in 22q11.2 deletion carriers.

The paper investigates the role of CSMD1 in opposing the complement cascade in neural tissues and links its dysfunction to schizophrenia risk.

The paper uses brain cell-type-specific protein interactomes to interpret genetic data in schizophrenia and identifies enriched networks and genes associated with the disease.

The paper identifies a protein-protein interaction network in human excitatory neurons for 13 ASD risk genes, revealing novel interactions and convergent mechanisms contributing to autism spectrum disorders.

Genoppi integrates proteomic and genetic data to identify cell-type-specific interactions and their role in disease.

The paper identifies BMI-associated metabolites using untargeted metabolomics and causal inference, finding both known and unknown metabolites with causal links to obesity.

PAIRUP-MS imputes and annotates unknown metabolite signals in mass spectrometry data, improving pathway analysis and meta-analysis power for metabolomics studies.