Hongxuan Chen

OpenBase: a universal framework for high-accuracy single-molecule detection of diverse non-canonical DNA bases using nanopore sequencing

OpenBase provides a framework for high-accuracy detection of diverse non-canonical DNA bases using nanopore sequencing through standardized training data and deep learning models.

Comprehensive analysis across mammalian tissues and cells decipher the underlying mechanism of m6A specificity

The paper identifies and characterizes m6A sites across human and mouse cell lines and tissues, revealing distinct features of high and low consistency m6A sites and their associations with gene regulation.