Author

Guan‐Zheng Luo

Sun Yat-sen UniversityORCID 0000-0002-6797-9319Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:long-read sequencing· 2 Organism:mouse· 2 Research Focus:database / resource· 1 Approach:deep learning· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Zhang ZhangiD· 3 shared Hongxuan CheniD· 2 shared Ying-Yuan XieiD· 2 shared Ze-Hui ReniD· 2 shared Zhen-Dong ZhongiD· 2 shared Zhi-Shuo Qiao· 2 shared Cai‐Guang YangiD· 1 shared Chen‐Long Wang· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBioinformatics

Zhang ZhangORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

OpenBase: a universal framework for high-accuracy single-molecule detection of diverse non-canonical DNA bases using nanopore sequencing

Zhen-Dong Zhong, Ying-Yuan Xie, Rujia Luo, Hongxuan Chen, Zhi-Shuo Qiao, Zehui Ren, Zhang Zhang, Guan‐Zheng Luo

OpenBase provides a framework for high-accuracy detection of diverse non-canonical DNA bases using nanopore sequencing through standardized training data and deep learning models.

bioRxiv · May 16, 2026 · PreprintBioinformatics

Deciphering the epitranscriptomic code of RNA degradation with nanopore direct RNA sequencing

Zhang Zhang, Chen‐Long Wang, Zhihao Zhang, Yifeng Huang, Ying-Yuan Xie, Zhen-Dong Zhong, Guo‐Run Tang, Ze-Hui Ren, Ye-Lin Lan, Jin‐Wen Kong, Zhi-Shuo Qiao, Tao-Wen Su, Hong-Xuan Chen, Q Wang, Ru‐Jia Luo, , Guan‐Zheng Luo

This study uses nanopore direct RNA sequencing to analyze how m6A modifications and poly(A) tail dynamics influence RNA degradation kinetics and isoform-specific decay.

bioRxiv · May 10, 2026 · PreprintBioinformatics

Comprehensive analysis across mammalian tissues and cells decipher the underlying mechanism of m6A specificity

Guoshi Chai, Hongxuan Chen, Dong-Zhao Ma, Ze-Hui Ren, Xuehong Liu, Guan‐Zheng Luo

The paper identifies and characterizes m6A sites across human and mouse cell lines and tissues, revealing distinct features of high and low consistency m6A sites and their associations with gene regulation.

bioRxiv · Apr 19, 2024 · PreprintBioinformatics

Single-base mapping of m6A by an antibody-independent method

Zhang Zhang, Li-Qian Chen, Yuli Zhao, Cai‐Guang Yang, Ian A. Roundtree, Zijie Scott Zhang, Jian Min Ren, Wei Xie, Chuan He, Guan‐Zheng Luo

This paper introduces an antibody-independent method for single-base m6A mapping, showing high reliability and conservation across species.

Science Advances · Jul 3, 2019Peer-reviewedGenetics