Yury Goltsev

This study maps the spatiotemporal changes in the bone marrow microenvironment during CML progression using single-cell and 3D imaging, revealing immune evasion and niche disruption.

The paper identifies spatial immune patterns in Merkel cell carcinoma linked to viral status and patient outcomes.

The paper introduces MARIO, a cell matching algorithm that integrates single-cell proteomic and multi-modal data, revealing orchestrated immune responses in lung tissue.

The paper discusses computational challenges in analyzing multiplexed imaging data and outlines community-driven approaches to address them through workshops and hackathons.

The paper uses CODEX multiplexed imaging to analyze mouse spleen architecture, revealing how cellular neighborhoods affect immune cell receptor expression and identifying altered cell interactions in lupus.