Cancer BiologybioRxivPreprint
POLQ-driven repair scars shape the immunogenic landscape of homologous recombination-deficient pancreatic cancer
Wungki Park, Shigeaki Umeda, Marc Hilmi…·Eileen Mary O'Reilly
The paper identifies MDF, a repair scar linked to POLQ-driven error-prone repair, as a marker of immune-responsive HRD pancreatic cancer with increased neoantigens and favorable clinical outcomes.
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