The paper identifies TIE CD8+ T cell clonotypes associated with prolonged survival in pancreatic cancer patients and links resistance to stromal and immune barriers.

bioRxiv · Sep 18, 2026 · PreprintCancer Biology

POLQ-driven repair scars shape the immunogenic landscape of homologous recombination-deficient pancreatic cancer

Wungki Park, Shigeaki Umeda, Marc Hilmi, Catherine Anne O'Connor, Roshan Sharma, Nuray Tezcan, Haochen Zhang, Yingjie Zhu, Carly Schwartz, Amin Yaqubie, Anna M. Varghese, Kevin Soares, Vaia Florou, DaeWon Kim, Steven Brad Maron, , Eileen Mary O'Reilly

The paper identifies MDF, a repair scar linked to POLQ-driven error-prone repair, as a marker of immune-responsive HRD pancreatic cancer with increased neoantigens and favorable clinical outcomes.

bioRxiv · Mar 17, 2026 · PreprintCancer Biology

Genomic evolution of pancreatic cancer at single-cell resolution

Haochen Zhang, Palash Sashittal, Elias-Ramzey R. Karnoub, Akhil Jakatdar, Shigeaki Umeda, Jungeui Hong, Anne Marie Noronha, Agustin Cardenas, Amanda Erakky, Caitlin A. McIntyre, Akimasa Hayashi, Nicolas Lecomte, Marc Hilmi, Wungki Park, Nan Pang, , Christine A. Iacobuzio–Donahue

This study uses single-nucleus DNA sequencing to analyze pancreatic cancer evolution, revealing patterns of mutation and copy number variation across clinical scenarios.

Nature Genetics · Jan 22, 2026Peer-reviewedCancer Biology

Transcriptomic plasticity is a hallmark of metastatic pancreatic cancer

Alejandro Jiménez-Sánchez, Sitara Persad, Akimasa Hayashi, Shigeaki Umeda, Roshan Sharma, Yubin Xie, Arnav Mehta, Wungki Park, Ignas Masilionis, Tinyi Chu, Feiyang Zhu, Jungeui Hong, Ronan Chaligné, Eileen Mary O'Reilly, Linas Mažutis, , Dana Pe’er

The paper analyzes transcriptomic changes in metastatic pancreatic cancer using a patient's autopsy data to identify site-specific gene programs and clonal phylogeny.

Cancer Research · Dec 11, 2025Peer-reviewedBioinformatics