Author
Memorial Sloan Kettering Cancer CenterORCID 0000-0001-5693-1515Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
6 papers
Recent·Most cited
Marc Hilmi, Joshua David Schoenfeld, Wilson McKerrow…·Wungki Park
The paper identifies TIE CD8+ T cell clonotypes associated with prolonged survival in pancreatic cancer patients and links resistance to stromal and immune barriers.
Christopher Beltz, Zekai Qiu, Leon Sadowski…·Thomas Walle
The paper introduces Suco and Compocyte to classify immune cells from 3,965 patients, identifying new macrophage and monocyte states and T cell memory erosion in metastases.
Wungki Park, Shigeaki Umeda, Marc Hilmi…·Eileen Mary O'Reilly
The paper identifies MDF, a repair scar linked to POLQ-driven error-prone repair, as a marker of immune-responsive HRD pancreatic cancer with increased neoantigens and favorable clinical outcomes.
X Zhang, W. Douglas Wong, Hyunwoo Cho…·Danwei Huangfu
This paper develops a human organoid model of early PDAC that identifies genetic and epigenetic barriers to lineage plasticity, showing CDKN2A loss is essential with KRAS/TP53 mutations and TET1 suppression links ERK signaling to transcription factor silencing.
Haochen Zhang, Palash Sashittal, Elias-Ramzey R. Karnoub…·Christine A. Iacobuzio–Donahue
This study uses single-nucleus DNA sequencing to analyze pancreatic cancer evolution, revealing patterns of mutation and copy number variation across clinical scenarios.
Alejandro Jiménez-Sánchez, Sitara Persad, Akimasa Hayashi…·Dana Pe’er
The paper analyzes transcriptomic changes in metastatic pancreatic cancer using a patient's autopsy data to identify site-specific gene programs and clonal phylogeny.