Author

Hoa Tran

BC Cancer AgencyORCID 0000-0002-9547-8650Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:whole-genome sequencing· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Ciara H. O’FlanaganiD· 3 shared Daniel LaiiD· 3 shared Elena ZaikovaiD· 3 shared Farhia KabeeriD· 3 shared Samuel A. J. R. AparicioiD· 3 shared Sean BeattyiD· 3 shared Teresa Ruiz de Algara· 3 shared Andrew J. L. RothiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Ciara H. O’FlanaganORCID

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3 papers

Recent·Most cited

Chromosomal mutational signatures of DNA damaging agents at single cell resolution

Mirela Andronescu, Alexander Adrian-Hamazaki, Damian Yap, William Daniels, Armaghan Sarvar, Elena Zaikova, Benjamin Furman, Vinci Au, Amelia Richter, Michael Van Vliet, Caroline Baril, Beixi Wang, Sean Beatty, Farhia Kabeer, Ciara H. O’Flanagan, , Samuel A. J. R. Aparicio

This paper develops a framework to analyze chromosomal mutational patterns at single-cell resolution, revealing drug-induced mutational signatures in human tissues.

bioRxiv · Sep 7, 2026 · PreprintCancer Biology

Somatic copy number mutations contribute to fitness in transplantation models of spontaneous human breast cancer metastasis

Hoa Tran, Gurdeep Singh, Hakwoo Lee, Damian Yap, Eric Lee, William Daniels, Farhia Kabeer, Ciara H. O’Flanagan, Vinci Au, Michael Van Vliet, Daniel Lai, Elena Zaikova, Sean Beatty, Esther Kong, Shuyu Fan, , Samuel A. J. R. Aparicio

This study shows that somatic copy number mutations (CNA) influence metastatic fitness in breast cancer by mediating transcriptional changes and affecting clone survival in different sites.

bioRxiv · Oct 27, 2025 · PreprintCancer Biology

Single cell decoding of drug induced transcriptomic reprogramming in triple negative breast cancers

Farhia Kabeer, Hoa Tran, Mirela Andronescu, Gurdeep Singh, Hakwoo Lee, Sohrab Salehi, Beixi Wang, Justina Biele, Jazmine Brimhall, David Gee, Viviana Cerda, Ciara H. O’Flanagan, Teresa Ruiz de Algara, Takako Kono, Sean Beatty, , Samuel A. J. R. Aparicio

The paper identifies genomic and non-genomic contributions to drug resistance in triple negative breast cancer using single cell transcriptomics and copy number data.

Genome biology · Jul 18, 2024Peer-reviewedGenomics