Zhiao Chen

The paper identifies 15,836 noncoding splice isoforms in human mRNA from 7,298 protein-coding genes, showing tissue-specific expression and association with cancer.

This study develops SRT-CD, a machine learning system using tumor- and tissue-specific RNA transcripts to diagnose cancers and determine tissue origin with high accuracy.

The paper defines the full-length transcriptome of primary and metastatic liver cancers and identifies isoform-level diversity and metastasis-specific transcripts with clinical implications.