Development of a pipeline to evaluate YAP-TEAD inhibitor potential - direct TEAD inhibition represses cancerous growth in a NF2-mutant model of mesothelioma
Richard Cunningham, Siyang Jia, Krishna Pinganksha Purohit, Michaela Nosková, Marcin K Maniak, Yue Lin, Ning Sze Hui, Rebecca E. Graham, Adriano Giorgio Rossi, Justyna Cholewa-Waclaw, Pierre Bagnaninchi, Neil O. Carragher, Carsten Gram Hansen
The paper develops a pipeline to compare YAP/TAZ-TEAD inhibitors in mesothelioma models, identifying genetic compensation and off-target effects.
Life Science Alliance · Jul 31, 2025Peer-reviewedCancer Biology