Neil O. Carragher

The paper identifies SMAD3-driven cell state transitions as a mechanism of immunoresistance in bladder cancer and shows that SMAD3 inhibition sensitizes tumors to T cell-mediated cytotoxicity.

This study assesses the reproducibility of a 3D spheroid-based assay across four institutes using dual-view oblique plane microscopy and finds high consistency in treatment effects with low technical noise.

This study screens a large compound library across patient-derived GBM stem cells to identify effective drugs targeting tumor heterogeneity and presents validated hits for further exploration.

This study shows SS18-SSX sustains oncogenic transcription without needing SWI/SNF activity, identifies P300 as a critical co-factor, and demonstrates targeting P300 or SWI/SNF as therapeutic strategies.

This study identifies three compounds targeting glioblastoma stem cells using machine learning and high-throughput screening of patient-derived models.

This study shows FAK regulates glycolysis and glutamine oxidation in glioblastoma stem cells, affecting mitochondrial morphology and cell migration.

The paper develops a pipeline to compare YAP/TAZ-TEAD inhibitors in mesothelioma models, identifying genetic compensation and off-target effects.

This paper identifies Flunarizine as a compound that inhibits radiation-induced astrocyte reactivity and improves survival in a glioblastoma model.

This study identifies a synergistic combination of FAK and MEK inhibitors that effectively targets glioblastoma heterogeneity and improves therapeutic outcomes.

This study shows that collagen scar formation during bile duct regeneration alters biomechanical properties, activating integrin-SRC/FAK signaling to drive ductular regeneration through a leading-tip of integrin-2-high cells.

This paper designs and evaluates Dyr726, a brain-penetrant multi-kinase inhibitor that targets PI3Kα, receptor tyrosine kinases, and WNT signaling, showing efficacy in preclinical cancer models.

The paper screens 1,429 compounds in primary human airway basal cells to identify Wnt pathway activators that promote proliferation and regeneration.

The paper identifies context-dependent gene essentiality in GBM using CRISPR screening and develops a platform to link biomarkers to therapeutic targets.

This study identifies a druggable PREX2/RAC1/PI3Kβ signalling axis in BRAF-mutant melanoma that confers resistance to therapies and can be targeted to improve treatment outcomes.

This study shows that FMRP loss in microglia increases RAC1 signaling, leading to inflammation and neuronal hyperexcitability in FXS, which can be mitigated by RAC1 inhibition.

The paper uses machine learning to identify senescent glioblastoma cells and discovers compounds that induce senescence in these cells.

The paper uses cell painting to identify drugs that reverse SORL1 deletion phenotypes in neural progenitor cells, revealing potential therapeutic targets for Alzheimer's disease.

The paper develops a high-content screen to identify inhibitors of mitochondrial DNA maintenance in trypanosomes and identifies a novel kDNA-targeting compound.

This study shows that Trichoplein regulates endothelial cell function by controlling autophagy, with implications for vascular health and coronary artery disease.

This study shows N-cadherin stabilizes neural identity by reducing anti-neural signals during differentiation.