Tony DeFalco

This study shows ovarian macrophages regulate germ cell meiotic entry, vascular growth, and germ cell clearance during oocyte reserve establishment.

Prenatal corticosteroid exposure disrupts immune-vascular interactions and impairs steroidogenesis in the fetal testis, revealing potentially widespread effects of a commonly used therapy.

This study identifies Nestin+ perivascular cells as contributors to endometrial epithelial regeneration through estrogen-stimulated suppression of Notch signaling.

The paper investigates the role of PDGFRA and ERK signaling in fetal testis morphogenesis and Leydig cell development using genetic and molecular approaches.

The paper identifies Nestin+ perivascular cells in mice as multipotent progenitors contributing to ovarian lineages and shows their role in folliculogenesis through Notch signaling.

The paper identifies the origins and developmental roles of testicular macrophages in mice, showing that fetal Sertoli cells recruit macrophages during a specific time window and that different macrophage populations have distinct functions in testis development.

This study shows that Cdc42 in Sertoli cells is essential for adult spermatogenesis, as its deletion leads to loss of spermatogenic cells and infertility.

The paper shows that deleting Mafb and Maf genes in fetal mouse gonads causes monocyte overproduction and defects in vascularization and testis development.

The paper identifies Polycomb's role in suppressing a female gene regulatory network in Sertoli cells to maintain testicular differentiation.