Author

Wenchang Zhao

Northeastern UniversityORCID 0000-0003-4144-8226Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Assay:CRISPR screen· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Fei TengiD· 2 shared Han ZhangiD· 2 shared Lumen ChaoiD· 2 shared Shengnan WangiD· 2 shared Wei LiiD· 2 shared Xiaolong ChengiD· 2 shared Zexu LiiD· 2 shared Zihan LiiD· 2 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioinformatics

Fei TengORCID

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2 papers

Recent·Most cited

BioinformaticsNature CommunicationsPeer-reviewedFeb 10, 2023

Modeling CRISPR-Cas13d on-target and off-target effects using machine learning approaches

Xiaolong Cheng, Zexu Li, Ruocheng Shan…·Wei Li

The paper develops DeepCas13, a deep learning model to predict CRISPR-Cas13d gRNA on-target activity and off-target viability effects, improving accuracy for RNA editing applications.

73 citationstop 2%

CRISPR screendeep learning

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Molecular BiologybioRxivPreprintMay 14, 2022

Intrinsic RNA targeting constrains the utility of CRISPR-Cas13 systems

Zexu Li, Zihan Li, Xiaolong Cheng…·Fei Teng

The paper evaluates CRISPR-Cas13 systems and finds that they have intrinsic RNA targets in mammalian cells, which can affect lentiviral particle production and limit their utility.

2 citations

humanCRISPR screen

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