Han Zhang

Diffusion Neuroimaging of Speech Acquisition in Infants

This study uses diffusion MRI to show that speech acquisition in infants involves coordinated white-matter maturation across multiple systems, not just language pathways.

Mutations in ClpC1 or ClpX subunit of the caseinolytic protease confer resistance to natural product ilamycins in mycobacteria

This study identifies two ilamycin analogs targeting mycobacterial Clp protease components and discovers mutations conferring resistance to these compounds.

EVODEX: A Mechanistic Framework for Extracting, Structuring, and Predicting Enzymatic Reactivity

EVODEX extracts and predicts enzymatic reactivity by defining partial reactions and Electronic Reaction Operators, achieving high accuracy in formula and mechanistic levels.

A comprehensive benchmark for multiple highly efficient base editors with broad targeting scope

The paper benchmarks multiple base editors and develops a model to predict editing efficiency, validating edits for disease-associated variants and identifying cancer-related SNVs.

Modeling CRISPR-Cas13d on-target and off-target effects using machine learning approaches

The paper develops DeepCas13, a deep learning model to predict CRISPR-Cas13d gRNA on-target activity and off-target viability effects, improving accuracy for RNA editing applications.

Intrinsic RNA targeting constrains the utility of CRISPR-Cas13 systems

The paper evaluates CRISPR-Cas13 systems and finds that they have intrinsic RNA targets in mammalian cells, which can affect lentiviral particle production and limit their utility.

Dissecting human skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses

This study maps the transcriptional landscape of human embryonic skeletogenesis at single-cell resolution, identifying distinct skeletal stem/progenitor cells and their lineage hierarchy.