Knowledge-graph-based cell-cell communication inference for spatially resolved transcriptomic data with SpaTalk
Xin Shao, Chengyu Li, Haihong Yang, Xiaoyan Lu, Jie Liao, Jingyang Qian, Kai Wang, Junyun Cheng, Penghui Yang, Huajun Chen, Xiao Xu, Xiaohui Fan
SpaTalk infers cell-cell communication from spatial transcriptomic data using a knowledge graph and graph network, outperforming existing methods on public datasets and revealing insights into tissue communication mechanisms.
Nature Communications · Jul 30, 2022Peer-reviewedBioinformatics