Chengyu Li

BrainBeacon is a cross-species foundation model for whole-brain spatial transcriptomics that enables cross-species alignment and uncovers spatial regulatory mechanisms of aging.

The paper introduces Translatomer, a transformer model that predicts cell-type-specific translation from mRNA and sequence data, identifies disease variants affecting translation, and reveals non-eQTL regulatory mechanisms.

SpaTalk infers cell-cell communication from spatial transcriptomic data using a knowledge graph and graph network, outperforming existing methods on public datasets and revealing insights into tissue communication mechanisms.